Description

Bimosiamose Disodium is a potent and selective small-molecule antagonist of sialyl Lewis X (sLex), a key carbohydrate ligand involved in inflammatory cell adhesion processes. This compound is of significant interest for its potential to inhibit leukocyte recruitment and endothelial adhesion, making it a valuable research tool for studying inflammatory pathways. It is primarily utilized by researchers and developers in the pharmaceutical and biotechnology sectors for preclinical investigation into inflammatory diseases, ischemia-reperfusion injury, and related therapeutic areas. The product is supplied as a high-purity material suitable for laboratory and research-scale applications.

Application

• Inflammation Research: Used as a key pharmacological tool to study the role of selectins and sLex in acute and chronic inflammatory models.
• Cardiovascular Disease Studies: Investigated for its potential to mitigate ischemia-reperfusion injury in myocardial infarction and stroke research.
• Immunology Assays: Employed in in vitro and in vivo assays to block E- and P-selectin mediated leukocyte adhesion and rolling.
• Drug Discovery & Development: Serves as a reference compound or starting point for the design of novel anti-inflammatory therapeutics targeting cell adhesion molecules.
• Oncology Research: Explored for modulating inflammatory components within the tumor microenvironment that influence cancer progression.

Basic Information

Product Name	Bimosiamose Disodium
CAS No.	187269-60-9
Molecular Formula	C19H23N3Na2O11S
Molecular Weight	547.44 g/mol
Synonyms	1,6-Bis(3-carboxy-2,4,6-trihydroxyphenylthio)-1,6-dideoxy-D-mannitol Disodium Salt; TBC-1269; Bimosiamose; Bimosiamose disodium salt; (1R,2R,3S,4S,5R,6S)-1,6-Bis(3-carboxy-2,4,6-trihydroxyphenylsulfanyl)hexane-1,2,3,4,5,6-hexol disodium salt; Anti-inflammatory agent TBC 1269; Selectin antagonist TBC-1269.
EINECS	Contact for details

Quality Control

Our Bimosiamose Disodium is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency. Each lot undergoes rigorous analytical testing, including HPLC for purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality system is designed to meet the stringent requirements of research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.