Description

Tetrahydro-2H-Pyran-2-Ylmethanesulfonyl Chloride is a specialized sulfonyl chloride derivative featuring a tetrahydropyranyl (THP) protecting group, making it a valuable reagent in synthetic organic chemistry. Its primary value lies in its dual functionality, where the sulfonyl chloride moiety acts as an excellent electrophile for sulfonylation reactions, while the THP group offers orthogonal protection for alcohols. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of complex molecules, intermediates, and active pharmaceutical ingredients (APIs) where selective protection and functionalization are required.

Application

• Pharmaceutical Intermediate Synthesis: A key building block for introducing sulfonamide or sulfonate ester functionalities into drug candidates and APIs.
• Alcohol Protection: Used to install the tetrahydropyranyl (THP) protecting group onto hydroxyl groups, offering stability under a wide range of reaction conditions.
• Sulfonylation Reagent: Employed in the preparation of sulfonamides, sulfonate esters, and other sulfonyl-containing compounds for biological screening.
• Agrochemical Research: Serves as a precursor in the development of novel herbicides, fungicides, and insecticides that incorporate sulfonyl-based active components.
• Material Science & Polymer Chemistry: Can be utilized to create functional monomers or cross-linking agents for specialty polymers.
• Chemical Biology & Proteomics: Acts as a reactive handle for bioconjugation or as a tool compound in probe development.

Basic Information

Product Name	Tetrahydro-2H-Pyran-2-Ylmethanesulfonyl Chloride
CAS No.	187164-16-5
Molecular Formula	C6H11ClO3S
Molecular Weight	198.67 g/mol
Synonyms	2-(Chlorosulfonylmethyl)tetrahydro-2H-pyran; THP-Methanesulfonyl Chloride; Tetrahydropyran-2-ylmethanesulfonyl chloride; (Tetrahydro-2H-pyran-2-yl)methanesulfonyl chloride; 2-(Methanesulfonylchloromethyl)tetrahydropyran; 187164-16-5; (Oxan-2-yl)methanesulfonyl chloride
EINECS	Contact for details

Quality Control

Our Tetrahydro-2H-Pyran-2-Ylmethanesulfonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and scale-up applications. We adhere to cGMP principles where applicable and support compliance with REACH and other global regulatory frameworks. Comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, is performed. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.