Description

7-Deoxy Doxorubicinol Aglycone is a key intermediate and reference standard in the synthesis and analytical profiling of anthracycline-based pharmaceuticals. This compound is of critical importance for research and development focused on novel chemotherapeutic agents and their metabolic pathways. It is primarily utilized by pharmaceutical R&D laboratories, analytical testing facilities, and manufacturers of active pharmaceutical ingredients (APIs) for quality control and process development.

Application

• Pharmaceutical Reference Standard: Used as a high-purity calibrant in analytical methods (HPLC, LC-MS) for the quantification of doxorubicin and related compounds in drug substances and products.
• Metabolite Research: Serves as a critical standard for studying the biotransformation and pharmacokinetics of anthracycline drugs in preclinical and clinical research.
• Process Chemistry Intermediate: Employed in the synthetic pathways for developing new anthracycline derivatives or analogs with potentially improved efficacy or reduced side effects.
• Impurity Identification: Essential for identifying and characterizing potential degradation products or process-related impurities in doxorubicin API manufacturing, supporting regulatory filings (e.g., ICH guidelines).
• Biochemical Research: Used in studies investigating the mechanism of action, cellular uptake, and resistance mechanisms associated with anthracycline chemotherapy.

Basic Information

Product Name	7-Deoxy Doxorubicinol Aglycone
CAS No.	187105-52-8
Molecular Formula	C₂₆H₂₈O₉
Molecular Weight	484.5 g/mol
Synonyms	7-Deoxydoxorubicinol Aglycone; 7-Deoxy-13-dihydrodoxorubicinone; (7S,9S)-7-Deoxy-9-hydroxy-10-[(2S,4S,5S,6S)-4-hydroxy-5-methoxy-6-methyloxan-2-yl]oxy-6,8,11-trihydroxy-7,8,9,10-tetrahydrotetracene-5,12-dione; Doxorubicinol Aglycone, 7-Deoxy-; 7-Deoxy Doxorubicinol; Aglycone of 7-Deoxydoxorubicinol
EINECS	Contact for details

Quality Control

Our 7-Deoxy Doxorubicinol Aglycone is manufactured under controlled conditions to ensure high chemical purity and batch-to-batch consistency, suitable for research and analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles as determined by advanced chromatographic and spectroscopic methods. We adhere to stringent internal quality standards to support the demanding requirements of pharmaceutical development and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	Red to orange-red powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.