Description

2-Fmoc-Amino Ethanesulfonyl Chloride is a specialized sulfonyl chloride derivative protected with a fluorenylmethyloxycarbonyl (Fmoc) group, serving as a key building block in synthetic organic chemistry. Its primary value lies in its dual functionality, enabling the controlled introduction of a protected amino group and a reactive sulfonyl chloride moiety for subsequent coupling reactions. This compound is essential for researchers and manufacturers in the pharmaceutical and bioconjugation sectors, particularly for the synthesis of peptide mimetics, sulfonamide-based drug candidates, and advanced molecular probes.

Application

• Peptide Synthesis: As a protected amino acid derivative for the solid-phase and solution-phase synthesis of complex peptides and peptidomimetics.
• Sulfonamide Library Production: A crucial intermediate for the high-throughput synthesis of diverse sulfonamide compounds for medicinal chemistry and drug discovery screening.
• Bioconjugation & Probe Development: Used to create labeled biomolecules, affinity tags, and fluorescent probes by reacting the sulfonyl chloride group with amines or hydroxyls on target molecules.
• Linker Chemistry: Employed in the construction of cleavable linkers for drug delivery systems, such as Antibody-Drug Conjugates (ADCs), and in materials science.
• Organic Synthesis Intermediate: Serves as a versatile reagent for introducing the 2-aminoethanesulfonyl moiety into more complex molecular architectures under mild conditions.

Basic Information

Product Name	2-Fmoc-Amino Ethanesulfonyl Chloride
CAS No.	187089-27-6
Molecular Formula	C₁₇H₁₆ClNO₄S
Molecular Weight	365.83 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-aminoethanesulfonyl chloride; 2-[(Fmoc-amino)ethanesulfonyl chloride; Fmoc-NH-CH2-CH2-SO2Cl; 2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)ethane-1-sulfonyl chloride; N-Fmoc-2-aminoethanesulfonyl chloride; N-(9-Fluorenylmethoxycarbonyl)-2-aminoethanesulfonyl chloride; 2-(Fmoc-amino)ethylsulfonyl chloride
EINECS	Contact for details

Quality Control

Every batch of 2-Fmoc-Amino Ethanesulfonyl Chloride is manufactured and tested under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for demanding research and scale-up applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, providing detailed results for identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Store away from strong bases and moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.