Description

Olanzapine Glucuronide is a major, pharmacologically relevant metabolite of the atypical antipsychotic drug Olanzapine. This compound is of critical importance for pharmaceutical research and development, serving as a key reference standard in bioanalytical studies. It is primarily utilized by research institutions, pharmaceutical companies, and contract research organizations (CROs) engaged in drug metabolism and pharmacokinetics (DMPK) research, therapeutic drug monitoring, and the development of robust analytical methods.

Application

• Pharmacokinetic and Metabolism Studies: Used as a certified reference standard to quantify Olanzapine glucuronide levels in biological matrices (plasma, urine) for DMPK profiling.
• Bioanalytical Method Development and Validation: Essential for calibrating HPLC, LC-MS, and LC-MS/MS systems to ensure accurate and reproducible assay performance.
• Therapeutic Drug Monitoring (TDM): Enables precise measurement of metabolite concentrations to optimize dosing regimens and assess patient adherence in clinical settings.
• Impurity Profiling and Characterization: Serves as a known impurity standard in the quality control of Olanzapine active pharmaceutical ingredient (API) and finished dosage forms.
• Clinical Research: Supports investigations into the correlation between metabolite levels, efficacy, and side-effect profiles of Olanzapine therapy.
• Regulatory Submissions: Provides essential data for regulatory filings (e.g., FDA, EMA) requiring comprehensive metabolite identification and quantification.

Basic Information

Product Name	Olanzapine Glucuronide
CAS No.	186792-80-3
Molecular Formula	C24H26FN3O7
Molecular Weight	487.48 g/mol
Synonyms	2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine Glucuronide; Olanzapine N-Glucuronide; Olanzapine Glucuronide Metabolite; LY170158 Glucuronide; Zyprexa Metabolite; 10H-Thieno[2,3-b][1,5]benzodiazepine, 2-methyl-4-(4-methyl-1-piperazinyl)-, β-D-glucopyranosiduronic acid derivative
EINECS	Contact for details

Quality Control

Our Olanzapine Glucuronide is manufactured under strict quality control protocols to ensure the high purity and consistency required for research and analytical applications. Each batch is thoroughly characterized using advanced spectroscopic and chromatographic techniques. A comprehensive Certificate of Analysis (COA) is provided, detailing purity, identity, and impurity profiles to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15°C and 25°C (59°F and 77°F). For long-term stability, storage at -20°C is recommended. Keep the container in a dry environment.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.