Description

Roscovitine CAS NO 186692-46-6 is a potent and selective small-molecule inhibitor of cyclin-dependent kinases (CDKs), specifically targeting CDK1, CDK2, CDK5, and CDK7. This compound is a critical research tool for investigating cell cycle regulation, apoptosis, and signal transduction pathways in various biological systems. It is primarily utilized by researchers and developers in the pharmaceutical, biotechnology, and academic sectors for drug discovery, target validation, and fundamental biochemical studies.

Application

• Biomedical Research: A key reagent for studying cell cycle progression, proliferation, and differentiation in cancer biology and other disease models.
• Drug Discovery & Development: Used as a reference standard and a lead compound in the development of novel CDK-targeted therapeutics for oncology.
• Signal Transduction Studies: Essential for elucidating the role of specific CDKs in intracellular signaling cascades and transcriptional regulation.
• Apoptosis Research: Employed to induce and investigate programmed cell death mechanisms in various cell lines.
• Neuroscience Research: Applied in studies exploring the role of CDK5 in neuronal function, development, and neurodegenerative diseases.
• Virology: Investigated for its potential to inhibit viral replication by interfering with host cell cycle machinery.

Basic Information

Product Name	Roscovitine
CAS No.	186692-46-6
Molecular Formula	C19H26N6O
Molecular Weight	354.45 g/mol
Synonyms	(R)-Roscovitine; Seliciclib; CYC202; (R)-2-[(1-Ethyl-2-hydroxyethyl)amino]-6-benzylamino-9-isopropylpurine; (2R)-2-({6-[(Phenylmethyl)amino]-9-(propan-2-yl)-9H-purin-2-yl}amino)butan-1-ol; N-[(9-Isopropyl-6-(phenylmethylamino)purin-2-yl]-(2R)-2-aminobutanol
EINECS	Contact for details

Quality Control

Our Roscovitine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications and test results is provided to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.