Description

(S)-Roscovitine CAS NO 186692-45-5 is a highly selective and potent inhibitor of cyclin-dependent kinases (CDKs), specifically CDK2, CDK7, and CDK9. This small molecule is a critical research tool for studying cell cycle regulation, apoptosis, and transcription, offering significant value in both basic research and drug discovery pipelines. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on oncology, neurodegenerative diseases, and virology.

Application

• Biomedical Research: A key pharmacological probe for investigating the mechanisms of cell cycle progression, transcription, and neuronal apoptosis in vitro and in vivo.
• Oncology Studies: Used to study the role of CDKs in cancer cell proliferation and to evaluate its potential as an anti-cancer therapeutic agent in preclinical models.
• Neurodegenerative Disease Research: Applied in studies exploring CDK inhibition as a therapeutic strategy for conditions like Alzheimer's disease, Parkinson's disease, and stroke.
• Virology Research: Investigated for its ability to inhibit viral replication by targeting host CDKs, particularly in studies of HIV, HPV, and herpesviruses.
• Drug Discovery & Development: Serves as a reference compound and a starting point for the design and synthesis of novel CDK inhibitors with improved pharmacological profiles.
• Signal Transduction Pathways: Essential for dissecting complex intracellular signaling networks that govern cell fate decisions, including differentiation and survival.

Basic Information

Product Name	(S)-Roscovitine
CAS No.	186692-45-5
Molecular Formula	C19H27N7O
Molecular Weight	369.47 g/mol
Synonyms	(R)-Roscovitine; Seliciclib; CYC202; (R)-Roscovitine; (2R)-2-({6-(Benzylamino)-9-isopropyl-9H-purin-2-yl}amino)butan-1-ol; (R)-2-((6-(Benzylamino)-9-isopropyl-9H-purin-2-yl)amino)butan-1-ol; N-[(9-Isopropyl-6-{[(1R)-1-methylpropyl]amino}-9H-purin-2-yl)]benzamide (common misnomer); CDK Inhibitor II
EINECS	Contact for details

Quality Control

Our (S)-Roscovitine is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant standards for research-grade biochemicals to support reproducible scientific results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.