Description

Seliciclib CAS NO 186692-44-4 is a potent and selective inhibitor of cyclin-dependent kinases (CDKs), specifically targeting CDK2, CDK7, and CDK9. This small molecule is a critical research tool for investigating cell cycle regulation, transcription, and apoptosis pathways. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in oncology and antiviral drug discovery programs.

Application

• Oncology Research: Investigation of cell cycle arrest and induction of apoptosis in various cancer cell lines.
• Antiviral Research: Study of transcriptional inhibition for potential applications against viral infections, including HIV.
• Mechanistic Studies: Tool compound for elucidating the roles of specific CDKs in cellular processes and disease models.
• Preclinical Development: Used in in vitro and in vivo studies to validate CDK inhibition as a therapeutic strategy.
• Biochemical Assays: Standard for high-throughput screening and enzymatic assays targeting CDK activity.
• Combination Therapy Studies: Research into synergistic effects with other chemotherapeutic or targeted agents.

Basic Information

Product Name	Seliciclib
CAS No.	186692-44-4
Molecular Formula	C19H26N6O
Molecular Weight	354.45 g/mol
Synonyms	Roscovitine; CYC202; (R)-Roscovitine; (R)-2-[(1-Ethyl-2-hydroxyethyl)amino]-6-benzylamino-9-isopropylpurine; Seliciclibum; 6-Benzylamino-2-[(R)-(1-ethyl-2-hydroxyethyl)amino]-9-isopropylpurine; (2R)-2-({6-[(Phenylmethyl)amino]-9-(propan-2-yl)-9H-purin-2-yl}amino)butan-1-ol
EINECS	Contact for details

Quality Control

Our Seliciclib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.