Description

Ic 261 CAS NO 186611-52-9 is a potent and selective inhibitor of casein kinase 1 delta/epsilon (CK1δ/ε), a key enzyme family involved in regulating circadian rhythms, Wnt signaling, and cell cycle progression. This compound is a critical research tool for studying the biological functions of CK1 isoforms and their roles in diseases such as cancer, neurodegenerative disorders, and sleep disorders. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in drug discovery, target validation, and fundamental biochemical pathway analysis.

Application

• Biochemical Research: Used as a selective pharmacological tool to inhibit CK1δ and CK1ε activity in in vitro enzyme assays and cell-based studies.
• Circadian Rhythm Studies: Applied in research investigating the molecular mechanisms of the biological clock, as CK1 isoforms phosphorylate core clock proteins.
• Oncology Research: Employed to probe the role of CK1 in Wnt/β-catenin signaling pathways and its implications in cancer cell proliferation and survival.
• Neurodegenerative Disease Models: Utilized in studies exploring tau protein phosphorylation and its connection to pathologies like Alzheimer's disease.
• Drug Discovery & Target Validation: Serves as a reference compound for screening and developing novel CK1 inhibitors for therapeutic applications.
• Signal Transduction Analysis: Helps delineate CK1-mediated phosphorylation events in various cellular signaling cascades.

Basic Information

Product Name	Ic 261
CAS No.	186611-52-9
Molecular Formula	C₂₁H₁₈N₄O₂
Molecular Weight	358.39 g/mol
Synonyms	IC-261; CK1 Inhibitor IC261; Casein Kinase I Inhibitor IC261; 3-[(2,4,6-Trimethoxyphenyl)methylidene]-1H-indol-2-one; (2E)-3-[(2,4,6-Trimethoxyphenyl)methylene]-1H-indol-2(3H)-one; 3-[(2,4,6-Trimethoxyphenyl)methylene]indolin-2-one
EINECS	Contact for details

Quality Control

Our Ic 261 is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and NMR for structural confirmation, to ensure consistency and reliability for research applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or CoA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light brown solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.