Description

5-Fluoro-2-Methylphenylmagnesium Bromide is a highly reactive organometallic reagent, specifically a Grignard reagent, essential for constructing complex organic frameworks. Its primary value lies in its ability to act as a powerful nucleophile, introducing the 5-fluoro-2-methylphenyl moiety into target molecules through carbon-carbon bond formation. This compound is critically needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediates: Key building block for synthesizing fluorinated drug candidates, including potential kinase inhibitors and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides where the fluoro-methylphenyl group enhances biological activity and environmental stability.
• Material Science Precursors: Serves as a monomer or coupling agent in the development of specialty polymers and liquid crystals with tailored electronic properties.
• Cross-Coupling Reactions: Employed in Kumada, Negishi, and related transition-metal catalyzed cross-coupling reactions to create biaryl structures.
• Nucleophilic Addition: Reacts with carbonyl compounds (aldehydes, ketones, esters) to produce secondary and tertiary alcohols with the fluoro-methylphenyl substituent.
• Custom Synthesis & Contract Research: A vital tool for custom synthesis organizations (CSOs) and R&D laboratories exploring new chemical entities (NCEs).

Basic Information

Item	Detail
Product Name	5-Fluoro-2-Methylphenylmagnesium Bromide
CAS No.	186496-59-3
Molecular Formula	C7H6FMgBr
Molecular Weight	213.33 g/mol
Synonyms	(5-Fluoro-2-methylphenyl)magnesium bromide; 2-Methyl-5-fluorophenylmagnesium bromide; 5-Fluoro-o-tolylmagnesium bromide; Magnesium, bromo(5-fluoro-2-methylphenyl)-; Grignard reagent, 5-fluoro-2-methylphenylmagnesium bromide; 5-Fluoro-2-methylphenylmagnesium bromide solution
EINECS	Contact for details

Quality Control

Every batch of 5-Fluoro-2-Methylphenylmagnesium Bromide is manufactured and tested under stringent quality management protocols. We provide comprehensive Certificates of Analysis (COA) detailing concentration (typically as a solution in THF or diethyl ether), assay by titration, and impurity profiles to ensure consistency and reliability for your critical synthetic steps. Our quality commitment supports cGMP and ISO 9001 standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. This material is easily oxidized (store under inert atmosphere) and highly volatile. It must be stored under an inert gas atmosphere (argon or nitrogen) in a cool, dry, well-ventilated area, away from heat and ignition sources. For solutions, store at recommended temperatures (often 2-8°C or as specified) and ensure containers are securely sealed to prevent solvent loss and moisture ingress.

Specification

Item	Specification
Appearance	Clear solution, typically colorless to light brown
Concentration	0.5 M to 2.0 M in THF or Et2O (Custom concentrations available)
Assay (Titration)	≥ 95% (of stated concentration)
Identification (IR/NMR)	Conforms to structure
Water Content (Karl Fischer)	≤ 100 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.