Description

Ortataxel is a potent semi-synthetic taxane derivative, a class of compounds renowned for their microtubule-stabilizing and anti-mitotic properties. This compound is of significant interest for advanced pharmaceutical research and development, particularly in the field of oncology. It serves as a critical pharmaceutical intermediate and reference standard for researchers and manufacturers developing next-generation chemotherapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel taxane-based anti-cancer drugs.
• Oncology Research: Used as a reference standard in biochemical and pharmacological studies to investigate mechanisms of action against various cancer cell lines.
• Drug Discovery & Development: Employed in preclinical research for evaluating efficacy, toxicity, and pharmacokinetic profiles of new chemotherapeutic candidates.
• Analytical Standard: Serves as a high-purity calibrant in analytical methods (e.g., HPLC, LC-MS) for quality control and impurity profiling of related pharmaceutical products.
• Academic Research: Utilized in university and institutional labs for studying microtubule dynamics and cell cycle inhibition.

Basic Information

Product Name	Ortataxel
CAS No.	186348-23-2
Molecular Formula	C45H53NO14
Molecular Weight	831.91 g/mol
Synonyms	Ortataxel; BMS-275183; IDN-5109; (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecah-6,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl (2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate; 9-Dihydro-13-acetylbaccatin III 9,10-acetonide 10-deacetoxy-10-(2',2'-dimethyl-4'-phenyl-5'-oxazolidinecarbonyl) docetaxel analog
EINECS	Contact for details

Quality Control

Our Ortataxel is manufactured under strict quality management systems to ensure the highest standards of purity and consistency, suitable for research and pharmaceutical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles as determined by advanced analytical techniques including HPLC and NMR. We adhere to cGMP guidelines where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.