Description

Cryptophycin is a potent macrocyclic depsipeptide natural product originally isolated from cyanobacteria. This compound is of significant interest in pharmaceutical research due to its powerful cytotoxic activity, functioning as a microtubule-disrupting agent. It serves as a crucial reference standard and a promising lead compound for researchers in oncology and drug discovery, particularly in the development of novel anti-mitotic chemotherapeutics.

Application

• Pharmaceutical Research & Development: As a high-purity reference standard for analytical method development and validation in drug discovery pipelines.
• Oncology Studies: Investigation of its mechanism of action as a potent tubulin polymerization inhibitor and inducer of apoptosis in cancer cell lines.
• Lead Compound Optimization: Serving as a structural scaffold for the semi-synthesis and evaluation of novel analogs with improved therapeutic indices.
• Biochemical Assays: Utilization in in vitro studies to explore cell cycle arrest and cytotoxicity profiles.
• Academic Research: Fundamental studies in natural product chemistry, biosynthesis, and structure-activity relationships (SAR).

Basic Information

Product Name	Cryptophycin
CAS No.	186256-67-7
Molecular Formula	C31H39ClN2O7
Molecular Weight	587.10 g/mol
Synonyms	Cryptophycin 1; Cryptophycin A; (3S,6R,10S,13R,16E,18S,21S,26aS)-13-[(2S)-2-Aminopropanoyl]oxy]-18-[(2R)-2-chloro-3-phenylpropanoyl]oxy]-3-[(1R)-1-hydroxyethyl]-10,21-dimethyl-1,4,7,12,15,20,23,26-octaoxo-6-(2-phenylethyl)-1,2,3,4,7,8,9,10,11,12,15,16,17,18,19,20,23,24,25,26,26a-henicosa hydro-11H-pyrido[2,1-s] [1,4,7,10,13,16,19]heptaoxacyclodocosin-11-yl acetate; ARA-A; LY355703
EINECS	Contact for details

Quality Control

Our Cryptophycin is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot is characterized using advanced analytical techniques including HPLC, MS, and NMR to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and hydrolysis. The material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.