Description

Pandinotoxin-K Alpha CAS NO 185529-64-0 is a highly specific, potent neurotoxin derived from scorpion venom. This compound is a critical research tool for studying voltage-gated potassium (Kv) channels, which are fundamental to neuronal signaling and cardiac function. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in neuroscience, ion channel pharmacology, and novel therapeutic discovery.

Application

• Neuroscience Research: Selective blockade of Kv channels to study neuronal excitability, synaptic transmission, and action potential propagation.
• Cardiovascular Research: Investigation of cardiac electrophysiology and the role of potassium channels in heart rhythm regulation.
• Drug Discovery & Development: High-throughput screening and validation of new compounds targeting potassium channelopathies for conditions like epilepsy, arrhythmia, and neuropathic pain.
• Toxicology Studies: Used as a reference standard in venom research and for understanding the mechanism of action of scorpion toxins.
• Biochemical Assay Development: A key reagent in developing functional cell-based assays and binding studies for ion channel targets.
• Academic & Teaching Laboratories: A precise molecular tool for graduate-level research and advanced studies in cellular physiology.

Basic Information

Product Name	Pandinotoxin-K Alpha
CAS No.	185529-64-0
Molecular Formula	C176H277N53O51S7
Molecular Weight	~4010.8 g/mol
Synonyms	Pandinotoxin Kα; Pi1 Toxin; Pi1; α-KTx 1.1; Potassium channel toxin α-KTx 1.1; Pandinus imperator toxin 1; Neurotoxin Pi1; K+ channel blocker Pi1; Pandinus toxin K-alpha
EINECS	Contact for details

Quality Control

Every batch of Pandinotoxin-K Alpha is produced and analyzed under stringent conditions to ensure the highest standards of purity and biological activity for research applications. Our quality assurance includes comprehensive analytical testing, including HPLC for purity and mass spectrometry for identity confirmation. A detailed Certificate of Analysis (COA) providing batch-specific data on purity, bioactivity, and endotoxin levels is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized powder at -20°C or below. Reconstituted solutions should be aliquoted and stored at -80°C to prevent repeated freeze-thaw cycles. This product is hygroscopic (moisture-sensitive); ensure containers are sealed under anhydrous conditions.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Biological Activity (IC50)	Specified per batch (nM range)
Endotoxin Level	< 1.0 EU/μg
Solubility	Soluble in aqueous buffers or DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.