Description

4-Bromo-2-Thiophenesulfonyl Chloride,97% CAS NO 185329-76-4 is a high-purity organosulfur building block primarily used as a key intermediate in advanced organic synthesis. This compound is valued for its reactive sulfonyl chloride group, which enables the introduction of the sulfonamide or sulfonate moiety into complex molecular architectures. It is essential for researchers and process chemists in the pharmaceutical, agrochemical, and material science industries developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of sulfonamide-based drug candidates, including enzyme inhibitors and receptor modulators.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides that incorporate thiophene and sulfonyl groups for enhanced activity.
• Material Science Research: Acts as a monomer or functionalization agent in the creation of conductive polymers, organic semiconductors, and advanced polymeric materials.
• Chemical Biology & Proteomics: Employed as a reactive handle for bioconjugation and the development of activity-based probes targeting cysteine residues or other nucleophiles.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs producing specialized, high-value compounds for client projects.

Basic Information

Product Name	4-Bromo-2-Thiophenesulfonyl Chloride,97%
CAS No.	185329-76-4
Molecular Formula	C4H2BrClO2S2
Molecular Weight	261.55 g/mol
Synonyms	4-Bromo-2-thiophenesulfonyl chloride; 4-Bromothiophene-2-sulfonyl chloride; 2-Thiophenesulfonyl chloride, 4-bromo-; 4-Bromo-thiophene-2-sulfonyl chloride; 185329-76-4; 4-Bromothiophene-2-sulfonylchloride; 4-Bromothiophene-2-SO2Cl
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-Thiophenesulfonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.