Description

5-Hydroxy Vioxx is a key pharmaceutical intermediate and reference standard, primarily known for its role in the synthesis and analytical profiling of Rofecoxib. This compound is critical for ensuring the quality, safety, and efficacy of related active pharmaceutical ingredients (APIs) and finished drug products. It is essential for research and development laboratories, quality control units, and manufacturing facilities within the global pharmaceutical and fine chemical industries.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of the COX-2 inhibitor Rofecoxib and its structural analogs.
• Analytical Reference Standard: Used for method development, validation, and routine quality control testing (e.g., HPLC, LC-MS) to identify and quantify impurities and degradants.
• Metabolite Studies: Employed in pharmacokinetic and drug metabolism research to study the biotransformation pathways of related pharmaceutical compounds.
• Process Development & Optimization: Serves as a benchmark in scaling up and optimizing synthetic routes for API manufacturing.
• Regulatory Compliance & Documentation: Provides essential data for regulatory filings (e.g., FDA, EMA) to demonstrate product characterization and control strategies.

Basic Information

Product Name	5-Hydroxy Vioxx
CAS No.	185147-17-5
Molecular Formula	C17H14O4S
Molecular Weight	314.36 g/mol
Synonyms	5-Hydroxy Rofecoxib; 4-[4-(Methylsulfonyl)phenyl]-3-phenyl-5-hydroxyfuran-2(5H)-one; 5-Hydroxy-4-(4-(methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one; Vioxx Hydroxy Impurity; Rofecoxib Related Compound; 5-OH Rofecoxib; 5-Hydroxyfuranone derivative of Rofecoxib
EINECS	Contact for details

Quality Control

Our 5-Hydroxy Vioxx is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical research and development. A detailed Certificate of Analysis (COA) with batch-specific data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.