Description

Acotiamide Hydrochloride is a high-purity pharmaceutical intermediate and active pharmaceutical ingredient (API) with significant therapeutic potential. This compound is primarily valued for its role as a novel prokinetic agent, targeting gastrointestinal motility disorders. It is essential for research institutions, pharmaceutical developers, and manufacturers focused on creating treatments for functional dyspepsia and related conditions. Our supply ensures the stringent quality and consistency required for preclinical and clinical development.

Application

• Pharmaceutical API Synthesis: Primary use as the active ingredient in the formulation of gastrointestinal prokinetic drugs.
• Clinical Research & Development: Critical for preclinical studies and clinical trials investigating treatments for functional dyspepsia (FD).
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical laboratories.
• Mechanistic Studies: Used in pharmacological research to study acetylcholinesterase inhibition and gastrointestinal motility pathways.
• Formulation Development: Employed in the development of solid oral dosage forms such as tablets and capsules.

Basic Information

Product Name	Acotiamide Hydrochloride
CAS No.	185104-11-4
Molecular Formula	C21H26ClN3O4S
Molecular Weight	452.0 g/mol
Synonyms	YM443; Acotiamide HCl; N-[2-[Bis(1-methylethyl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxamide Hydrochloride; (4-Carbamoyl-2-[[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazol-5-yl]-N,N-diisopropylazanium Chloride; Z-338 Hydrochloride; YM-443 Hydrochloride
EINECS	Contact for details

Quality Control

Our Acotiamide Hydrochloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical use. Certificates of Analysis (COA) with detailed batch-specific results are provided and can be tailored to meet specific pharmacopeial or client requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.