Description

3-Fluoro-2-Methylphenylmagnesium Bromide is a highly reactive organometallic reagent, specifically a Grignard reagent, essential for forming new carbon-carbon bonds in complex organic syntheses. Its core value lies in introducing the versatile 3-fluoro-2-methylphenyl moiety into target molecules, enabling the precise construction of advanced chemical architectures. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate Synthesis: Key building block for constructing fluorinated drug candidates, particularly in central nervous system (CNS) and oncology research.
• Agrochemical Active Ingredient Development: Used to synthesize novel herbicides, fungicides, and insecticides where the fluorine atom enhances biological activity and metabolic stability.
• Ligand and Catalyst Preparation: Serves as a precursor for creating specialized phosphine or N-heterocyclic carbene (NHC) ligands used in asymmetric catalysis.
• Material Science Research: Employed in the synthesis of fluorinated organic semiconductors, liquid crystals, and polymers for electronic applications.
• Cross-Coupling Reactions: A crucial reagent in Kumada, Negishi, and related cross-coupling methodologies to create biaryl and other complex structures.
• Nucleophilic Addition Reactions: Reacts with carbonyl compounds (ketones, aldehydes, esters) and epoxides to form new alcohols and extended carbon chains.

Basic Information

Item	Details
Product Name	3-Fluoro-2-Methylphenylmagnesium Bromide
CAS No.	185077-02-5
Molecular Formula	C7H6BrFMg
Molecular Weight	213.33 g/mol
Synonyms	(3-Fluoro-2-methylphenyl)magnesium bromide; 2-Methyl-3-fluorophenylmagnesium bromide; 3-Fluoro-o-tolylmagnesium bromide; Magnesium, bromo(3-fluoro-2-methylphenyl)-; Grignard reagent 3-fluoro-2-methylphenyl; 3-Fluoro-2-methylphenylmagnesium bromide solution; 2-Methyl-3-fluorophenyl Grignard reagent; (2-Methyl-3-fluorophenyl)magnesium bromide
EINECS	Contact for details

Quality Control

Every batch of 3-Fluoro-2-Methylphenylmagnesium Bromide is manufactured and handled under stringent inert atmosphere conditions to ensure reactivity and purity. Our quality system adheres to cGMP principles where applicable, and all materials are supported by comprehensive analytical data. A Certificate of Analysis (COA) detailing assay (by titration), solvent content, and impurity profile is provided with each shipment to guarantee consistency and support your regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. This material is hygroscopic (moisture-sensitive) and easily oxidized (store under inert atmosphere). For optimal stability and to maintain reagent activity, store under a dry, inert gas (argon or nitrogen) atmosphere at 2-8°C. The container must be kept tightly sealed and only accessed in a moisture-free environment.

Specification

Item	Specification
Appearance	Clear, colorless to light brown solution
Concentration (in THF or Ether)	0.5 M - 2.0 M (Custom concentrations available)
Assay (Titration)	≥ 95% (of stated concentration)
Identification (IR / NMR)	Conforms to structure
Water Content (Karl Fischer)	≤ 100 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.