Description

(8R,9S,10R,13S,14S)-10,13-Dimethylspiro[7,8,9,11,12,13,15,16-Octahydro-6H-Cyclopenta[A]Phenanthrene-6,2'-Oxirane]-3,17(10H,14H)-Dione is a high-purity, complex steroidal spiro-oxirane derivative of significant interest in advanced organic synthesis. This compound serves as a critical chiral building block for the development of novel pharmaceuticals and bioactive molecules, particularly those targeting hormone-related pathways. It is essential for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries who require highly specific and structurally defined intermediates for complex synthetic routes.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and synthesis of novel steroidal drugs, hormone modulators, and enzyme inhibitors.
• Advanced Organic Synthesis: Used as a sophisticated building block in complex multi-step syntheses, leveraging its spiro-oxirane and diketone functionalities.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs) for therapeutic applications.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Biochemical Research: Potential use as a probe or precursor in studying steroid receptor interactions and metabolic pathways.
• Fine Chemical Production: Intermediate in the manufacture of specialty chemicals requiring a complex, polycyclic steroidal framework.

Basic Information

Product Name	(8R,9S,10R,13S,14S)-10,13-Dimethylspiro[7,8,9,11,12,13,15,16-Octahydro-6H-Cyclopenta[A]Phenanthrene-6,2'-Oxirane]-3,17(10H,14H)-Dione
CAS No.	184972-12-1
Molecular Formula	C20H26O3
Molecular Weight	314.42 g/mol
Synonyms	10,13-Dimethylspiro[cyclopenta[a]phenanthrene-6,2'-oxirane]-3,17-dione; (8R,9S,10R,13S,14S)-Spiro[estra-4,9-diene-6,2'-oxirane]-3,17-dione; Steroidal Spiro-oxirane Dione; 6,2'-Oxiranespiro-estra-4,9-diene-3,17-dione; 184972-12-1; Spiro-oxirane steroid derivative
EINECS	Contact for details

Quality Control

Our (8R,9S,10R,13S,14H)-10,13-Dimethylspiro[7,8,9,11,12,13,15,16-Octahydro-6H-Cyclopenta[A]Phenanthrene-6,2'-Oxirane]-3,17(10H,14H)-Dione is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis to confirm stereochemical integrity, ensuring it meets the stringent requirements for research and development use. A detailed Certificate of Analysis (COA) with batch-specific data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.