Description

4-Fluoro-3-(trifluoromethyl)benzyl bromide is a versatile and high-value fluorinated benzyl bromide derivative, serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring both fluorine and trifluoromethyl groups, imparts unique electronic and steric properties essential for modifying the pharmacokinetic profiles of target molecules. This compound is particularly valuable for researchers and process chemists in the pharmaceutical and agrochemical industries who require reliable, high-purity intermediates for developing new active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially in the development of kinase inhibitors, anti-cancer agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the fluorine and trifluoromethyl groups enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Acts as a precursor for fluorinated aromatic compounds used in electronic materials, contributing to improved performance in displays and organic light-emitting diodes.
• Functional Material Development: Employed in polymer science and material engineering to introduce fluorinated benzyl groups, modifying surface properties and chemical resistance.
• Cross-Coupling Reactions: Serves as an electrophilic partner in various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) to construct complex biaryl systems.
• Protecting Group Chemistry: Can be utilized to introduce the benzyl bromide moiety as a protecting group or a handle for further functionalization in multi-step synthetic routes.

Basic Information

Product Name	4-Fluoro-3-(trifluoromethyl)benzyl bromide
CAS No.	184970-26-1
Molecular Formula	C8H5BrF4
Molecular Weight	257.03 g/mol
Synonyms	1-(Bromomethyl)-4-fluoro-3-(trifluoromethyl)benzene; α-Bromo-4-fluoro-alpha,alpha,α-trifluoro-m-xylene; 4-Fluoro-3-trifluoromethylbenzyl Bromide; (4-Fluoro-3-(trifluoromethyl)phenyl)methyl bromide; 3-Trifluoromethyl-4-fluorobenzyl Bromide; m-Trifluoromethyl-p-fluorobenzyl Bromide; 4-Fluoro-α,α,α-trifluoro-m-tolyl bromide
EINECS	Contact for details

Quality Control

Our 4-Fluoro-3-(trifluoromethyl)benzyl bromide is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high chemical purity and identity confirmation. We provide detailed Certificates of Analysis (COA) with each shipment, documenting all critical parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability, consistency, and reliability for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is necessary to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.