Description

6-Ethyl Guanine-D5 is a stable isotope-labeled analog of 6-ethylguanine, where five hydrogen atoms are replaced by deuterium. This high-purity labeled compound is essential for advanced analytical research, providing an internal standard for precise quantification and metabolic pathway tracing. It is primarily utilized by pharmaceutical researchers, contract research organizations (CROs), and analytical laboratories engaged in drug metabolism and pharmacokinetics (DMPK) studies, biomarker analysis, and mass spectrometry.

Application

• Internal Standard for LC-MS/MS: Serves as a critical deuterated internal standard for the accurate quantification of 6-ethylguanine and related metabolites in complex biological matrices via liquid chromatography-tandem mass spectrometry.
• Drug Metabolism Studies (DMPK): Used in pharmaceutical R&D to investigate the metabolic fate, bioavailability, and excretion pathways of drug candidates and xenobiotics that form 6-ethylguanine adducts.
• Biomarker Research: Enables precise measurement of 6-ethylguanine as a potential biomarker of exposure to specific alkylating agents or environmental toxins.
• Toxicological and Carcinogenicity Research: Facilitates studies on DNA alkylation damage, repair mechanisms, and the role of specific guanine adducts in mutagenesis.
• Isotope Dilution Mass Spectrometry (IDMS): Employed in high-accuracy analytical methods that require isotope dilution for ultimate precision in clinical or forensic analysis.
• Reference Material for Method Development: Acts as a certified reference material for developing, validating, and calibrating sensitive analytical methods in regulated laboratories.

Basic Information

Product Name	6-Ethyl Guanine-D5
CAS No.	183558-84-1
Molecular Formula	C7H5D5N5O
Molecular Weight	183.20 g/mol
Synonyms	6-Ethyl-2-amino-1,7-dihydro-6H-purin-6-one-d5; 6-Ethylguanine-d5; Deuterated 6-Ethylguanine; 2-Amino-6-ethylpurine-d5; Guanin-6-ethyl-d5; 6-EtG-d5; [2H5]-6-Ethylguanine; 6-Ethyl-1H-purin-2-amine-6-ol-d5
EINECS	Contact for details

Quality Control

Our 6-Ethyl Guanine-D5 is manufactured under strict quality control protocols to ensure exceptional isotopic purity and chemical integrity, suitable for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (D-content), chemical purity by HPLC, and identity confirmation. We adhere to ISO 9001 quality management principles, and our processes are designed to meet the stringent requirements of GMP-aligned research and development.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.