Description

Apicidin is a potent, naturally occurring fungal metabolite belonging to the class of cyclic tetrapeptide histone deacetylase (HDAC) inhibitors. This compound is a critical research tool for studying epigenetic regulation, cell cycle progression, and gene expression in various biological systems. It is primarily utilized by researchers and developers in the pharmaceutical, biotechnology, and life sciences sectors for drug discovery, target validation, and fundamental biochemical research.

Application

• Biochemical Research: A selective inhibitor for studying the role of histone deacetylases (HDACs) in chromatin remodeling and epigenetic control.
• Antiparasitic Studies: Investigated for its potent activity against apicomplexan parasites, including Plasmodium spp. (malaria) and Toxoplasma gondii.
• Oncology Research: Used in cancer research to induce cell cycle arrest, differentiation, and apoptosis in various tumor cell lines.
• Anti-fungal Agent Development: Serves as a lead compound and reference standard in the development of novel antifungal therapeutics.
• Cell Signaling Pathways: A tool compound for dissecting signaling pathways involved in cell proliferation, inflammation, and immune response.
• Reference Standard: Employed as a high-purity analytical standard in quality control and method development for pharmaceutical analysis.

Basic Information

Product Name	Apicidin
CAS No.	183506-66-3
Molecular Formula	C34H49N5O6
Molecular Weight	623.79 g/mol
Synonyms	Apicidin; Cyclo[(2S)-2-Amino-8-oxodecanoyl-L-tryptophyl-D-pipecolinyl-L-2-amino-8-oxodecanoyl-L-2-aminobutanoyl]; FR 235222; HDAC Inhibitor Apicidin; [S-(E)]-Cyclo(L-2-Aminooxalyl-α-aminobutyryl-N-methyl-L-tryptophyl-D-pipecolinyl-L-2-aminooxalyll-α-aminobutyric Acid δ-Lactone); UNII-8K7W0K115Y
EINECS	Contact for details

Quality Control

Our Apicidin is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.