Description

Cabazitaxel is a semi-synthetic taxane derivative and a potent microtubule inhibitor used in advanced cancer therapy. This compound matters because it represents a critical second-line treatment option for hormone-refractory metastatic prostate cancer, offering a mechanism of action that remains effective against tumors resistant to other chemotherapeutic agents. It is primarily needed by pharmaceutical manufacturers, research institutions, and contract development and manufacturing organizations (CDMOs) engaged in oncology drug development and production.

Application

• Active Pharmaceutical Ingredient (API) in the formulation of injectable anticancer drugs.
• Key intermediate in advanced pharmaceutical research for novel taxane-based therapies.
• Reference standard in analytical laboratories for quality control and method development.
• Biochemical research tool for studying microtubule dynamics and cell division mechanisms.
• Development of targeted drug delivery systems and combination therapies.

Basic Information

Product Name	Cabazitaxel
CAS No.	183133-96-2
Molecular Formula	C45H57NO14
Molecular Weight	835.93 g/mol
Synonyms	XRP6258; RPR-116258A; Cabazitaxel Anhydrous; (2α,5β,7β,10β,13α)-4-Acetoxy-13-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1-hydroxy-7,10-dimethoxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate; Jevtana (brand name); TXD258
EINECS	Contact for details

Quality Control

Our Cabazitaxel CAS NO 183133-96-2 is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and stringent control of related substances and residual solvents to ensure compliance with ICH guidelines and relevant pharmacopeial standards. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurities is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. Keep the container in a dry, cool, and well-ventilated area. For long-term storage, consider conditions under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤1.0%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.