Description

4-Cyanopyridine-2-Sulfonyl Chloride is a versatile and highly reactive organic intermediate, primarily valued for its role as a key building block in advanced chemical synthesis. Its core value proposition lies in enabling the efficient introduction of the sulfonyl chloride and cyano functional groups, which are critical for constructing complex molecular architectures. This compound is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries, where it is used to create novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of sulfonamide-based drug candidates, including enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides that require the sulfonyl moiety for biological activity.
• Functional Material Development: Serves as a building block for creating advanced polymers, ligands for catalysis, and organic electronic materials.
• Chemical Biology & Proteomics: Employed as a reactive handle for bioconjugation and the design of activity-based probes for target identification.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects and scale-up production under cGMP conditions for clinical trial materials.
• Research & Development: Fundamental reagent in academic and industrial R&D labs for exploring new synthetic methodologies and heterocyclic chemistry.

Basic Information

Product Name	4-Cyanopyridine-2-Sulfonyl Chloride
CAS No.	181929-38-4
Molecular Formula	C6H3ClN2O2S
Molecular Weight	202.62 g/mol
Synonyms	2-Pyridinesulfonyl chloride, 4-cyano-; 4-Cyano-2-pyridinesulfonyl chloride; 4-Cyanopyridine-2-sulfonyl chloride; 2-Pyridinesulfonyl chloride, 4-cyano-; 4-Cyanopyridine-2-sulfonylchloride; 4-Cyano-2-sulfonylchloridopyridine; 181929-38-4; 4-CN-Py-2-SO2Cl
EINECS	Contact for details

Quality Control

Our 4-Cyanopyridine-2-Sulfonyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure high purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. For projects requiring specific regulatory support, we can supply material with documentation suitable for cGMP applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in a desiccator to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.