Description

Cytosine, [2-13C-1,3-15N2, 99 Atom % 13C, 99 Atom % 15N2] is a high-purity, isotopically labeled derivative of the fundamental nucleobase cytosine, specifically enriched with stable isotopes at key positions. This compound is essential for advanced research and development where precise molecular tracking and quantification are required. It is primarily utilized by scientists and manufacturers in the pharmaceutical, biotechnology, and analytical chemistry sectors for applications such as metabolic pathway studies, NMR spectroscopy, and the development of labeled pharmaceuticals.

Application

• Metabolic Flux Analysis (MFA): Used as a tracer to study and quantify intracellular metabolic pathways in biological systems.
• NMR Spectroscopy: Serves as a critical standard and probe in Nuclear Magnetic Resonance studies for structural elucidation and dynamic analysis of biomolecules.
• Mass Spectrometry: Employed as an internal standard for the accurate quantification of cytosine and its derivatives in complex matrices via LC-MS or GC-MS.
• Pharmaceutical R&D: Integral in the development and testing of isotopically labeled drug candidates, prodrugs, and diagnostic agents.
• Biochemical Research: Facilitates mechanistic studies of enzyme kinetics, nucleic acid synthesis, and repair processes.
• Environmental & Nutritional Tracing: Applied in studies tracking the incorporation of nucleotides in environmental microbiology or nutritional science.

Basic Information

Product Name	Cytosine, [2-13C-1,3-15N2, 99 Atom % 13C, 99 Atom % 15N2]
CAS No.	181517-10-2
Molecular Formula	C4[13C]H5N2[15N]2O
Molecular Weight	114.07 g/mol (for labeled form)
Synonyms	4-Amino-2(1H)-pyrimidinone, [2-13C-1,3-15N2]; 2-Oxy-4-aminopyrimidine, [2-13C-1,3-15N2]; [2-13C-1,3-15N2]Cytosine; 13C15N2-Cytosine; Cytosine-2-13C,1,3-15N2; Isotopically labeled cytosine; Stable isotope-labeled cytosine
EINECS	Contact for details

Quality Control

Every batch of our isotopically labeled cytosine is produced and analyzed under stringent quality protocols to ensure exceptional chemical and isotopic purity. Quality is verified through advanced analytical techniques including NMR, HPLC, and Mass Spectrometry. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing the isotopic enrichment (Atom %), chemical purity, and results of all specified tests to meet the exacting standards of research and regulatory applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccated or inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Isotopic Enrichment (Atom % 13C)	≥ 99%
Isotopic Enrichment (Atom % 15N2)	≥ 99%
Chemical Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.