Description

1,1'-Carbonyldiimidazole-13C is a stable isotope-labeled version of the versatile coupling reagent CDI, where the carbonyl carbon is enriched with the 13C isotope. This labeled compound is essential for advanced research and development, enabling precise tracking and mechanistic studies in chemical and biochemical reactions. It is primarily used by scientists and manufacturers in the pharmaceutical, agrochemical, and analytical chemistry sectors who require high-fidelity isotopic tracers for metabolic studies, reaction pathway elucidation, and as an internal standard for quantitative mass spectrometry.

Application

• Isotopic Tracer in Pharmaceutical R&D: Used to study drug metabolism, pharmacokinetics, and the metabolic fate of active pharmaceutical ingredients (APIs) synthesized using CDI chemistry.
• Mechanistic Reaction Studies: Employed as a 13C-labeled probe to elucidate reaction mechanisms and intermediates in peptide coupling, esterification, and other CDI-mediated transformations.
• Internal Standard for Quantitative Analysis: Serves as a critical internal standard in LC-MS and GC-MS methods for the accurate quantification of unlabeled CDI or its reaction products.
• Synthesis of Labeled Compounds: A key reagent for introducing a 13C label into target molecules, such as isotopically labeled peptides, polymers, or complex natural products.
• Biochemical Research: Utilized in the study of enzyme mechanisms and biochemical pathways where a 13C label from the carbonyl group provides crucial structural and kinetic information.

Basic Information

Product Name	1,1'-Carbonyldiimidazole-13C
CAS No.	181517-09-9
Molecular Formula	C713CH6N4O
Molecular Weight	163.13 g/mol (for 13C1 labeled form)
Synonyms	CDI-13C; 1,1'-Carbonyl-diimidazole-13C; N,N'-Carbonyldiimidazole-13C; Carbonyldiimidazole-13C; Imidazole, 1,1'-carbonylbis-, 13C-labeled; 1,1'-(13C)Carbonylbis(1H-imidazole); [13C]CDI
EINECS	Contact for details

Quality Control

Our 1,1'-Carbonyldiimidazole-13C is manufactured under strict quality control protocols to ensure high isotopic and chemical purity. Each batch is characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry to confirm the 13C enrichment level and chemical identity. Certificates of Analysis (COA) detailing isotopic purity, chemical purity, and assay are provided and can be tailored to meet specific research or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere to maintain stability and prevent decomposition. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure (13C label confirmed)
Assay (HPLC)	≥ 98.0%
Isotopic Purity (13C)	≥ 99 atom % 13C
Chemical Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.