Description

Z-Leu-Leu-4,5-Dehydro-Leu-Aldehyde is a potent and selective proteasome inhibitor, specifically targeting the chymotrypsin-like activity. This compound is a critical research tool for studying protein degradation pathways, cellular apoptosis, and inflammation. It is essential for pharmaceutical R&D, academic research, and biotechnology applications focused on cancer, neurodegenerative diseases, and immunology.

Application

• Biochemical Research: A key inhibitor for studying the 26S proteasome complex and ubiquitin-proteasome system (UPS) function in vitro.
• Drug Discovery: Used as a reference standard and pharmacological probe in the development of novel anti-cancer and anti-inflammatory therapeutics.
• Cell Biology Studies: Employed to induce apoptosis and investigate protein turnover, cell cycle regulation, and signal transduction pathways.
• Enzyme Mechanism Analysis: Serves as a substrate analog and active-site titrant for characterizing protease and proteasome kinetics.
• Neuroscience Research: Applied in models to understand the role of proteasomal degradation in neurodegenerative conditions like Alzheimer's and Parkinson's disease.

Basic Information

Product Name	Z-Leu-Leu-4,5-Dehydro-Leu-Aldehyde
CAS No.	181139-85-5
Molecular Formula	C₂₃H₃₉N₃O₅
Molecular Weight	437.58 g/mol
Synonyms	Z-LLL-CHO; Z-Leu-Leu-δLeu-H; MG-132 (analog); Carbobenzoxy-Leu-Leu-4,5-Dehydro-Leucinal; N-Benzyloxycarbonyl-L-leucyl-L-leucyl-(2S)-2-amino-4-methyl-4-pentenal; Proteasome Inhibitor I; Calpain Inhibitor I (related); (S)-2-((S)-2-((S)-3-((Benzyloxy)carbonyl)amino)-4-methylpentanamido)-4-methylpentanamido)-4-methylpent-4-enal
EINECS	Contact for details

Quality Control

Our Z-Leu-Leu-4,5-Dehydro-Leu-Aldehyde is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ISO 9001 standards, and our analytical methods, including HPLC and NMR, are validated to provide reliable data for your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, freezer environment. This compound is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; Slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.