Description

Fti 277 Hydrochloride is a potent and selective inhibitor of the farnesyltransferase enzyme, a key target in oncological and biomedical research. This compound is critical for studying signal transduction pathways involved in cell proliferation and has shown significant potential in the development of novel cancer therapeutics. It is an essential research-grade biochemical for pharmaceutical R&D, academic institutions, and biotechnology companies focused on oncology, molecular biology, and drug discovery.

Application

• Oncological Research: Used as a key pharmacological tool to study Ras protein signaling pathways and their role in cancer cell growth and survival.
• Drug Discovery & Development: Serves as a reference standard and active compound in high-throughput screening and preclinical studies for novel anticancer agents.
• Biochemical Assays: Employed in enzymatic assays to evaluate farnesyltransferase inhibition and to characterize the mechanism of action of new chemical entities.
• Academic Research: Utilized in university and institutional labs for fundamental research in cell biology, signal transduction, and molecular pharmacology.
• Pharmaceutical Intermediates: Acts as a critical synthetic intermediate or precursor in the multi-step synthesis of more complex therapeutic candidates.

Basic Information

Product Name	Fti 277 Hydrochloride
CAS No.	180977-34-8
Molecular Formula	C27H30N4O3 • HCl
Molecular Weight	503.02 g/mol
Synonyms	Fti-277 HCl; (S)-6-[(2R,5S)-5-[(2S)-2-Amino-3-mercaptopropyl]-2-methylpiperazin-1-yl]-5-[(2S)-3-phenyl-2-(phenylmethoxycarbonylamino)propanamido]-6-oxohexanoic acid hydrochloride; Farnesyltransferase Inhibitor 277 hydrochloride; (S)-[5-[4-(2R,5S)-2-C-[(1S)-1-Amino-2-mercaptoethyl]-5-methyl-1-piperazinyl]-2-phenyl-4-pentenoyl]amino]-6-phenyl-2-(phenylmethoxy)-N-[(1S)-1-phenylethyl]hexanamide hydrochloride
EINECS	Contact for details

Quality Control

Our Fti 277 Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with our stringent in-house specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. Keep the container tightly sealed in a cool, dry, and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.