Description

Lasofoxifene is a third-generation selective estrogen receptor modulator (SERM) with a distinct chemical structure. It is primarily valued for its targeted pharmacological activity in modulating estrogen receptor function in specific tissues. This compound is of significant interest to the pharmaceutical and life science research sectors for the development and study of novel therapeutic agents. Lasofoxifene CAS NO 180916-16-9 represents a high-purity advanced intermediate or active pharmaceutical ingredient (API) for critical R&D and manufacturing processes.

Application

• Pharmaceutical API Intermediate: Serves as a key building block in the synthesis of finished dosage forms for clinical and commercial use.
• Biomedical Research: Used as a reference standard or experimental compound in studies of estrogen receptor biology, bone metabolism, and oncology.
• Drug Discovery & Development: Employed in preclinical research for evaluating the efficacy and safety profile of SERM-based therapies.
• Analytical Standard: Provides a high-purity benchmark for quality control and method validation in analytical laboratories (HPLC, LC-MS).
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and cGMP production.

Basic Information

Product Name	Lasofoxifene
CAS No.	180916-16-9
Molecular Formula	C₂₈H₃₁NO₂
Molecular Weight	413.55 g/mol
Synonyms	(5R,6S)-6-Phenyl-5-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-5,6,7,8-tetrahydronaphthalen-2-ol; CP-336,156; Fablyn; Lasofoxifene tartrate (salt form); Bevaser; Oporia; Selective Estrogen Receptor Modulator (SERM) CP-336156
EINECS	Contact for details

Quality Control

Our Lasofoxifene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and support regulatory filings. Certificates of Analysis (COA) documenting compliance with specifications are available for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Unknown Impurity	≤0.5%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.