Description

Hexakis-(6-Mercapto-6-Deoxy)-α-Cyclodextrin is a multifunctional, thiolated derivative of α-cyclodextrin, engineered to introduce reactive sulfhydryl groups onto the cyclic oligosaccharide scaffold. This modification is critical for applications requiring covalent bonding, cross-linking, or surface functionalization, leveraging the unique host-guest properties of cyclodextrins. It is essential for researchers and formulators in the pharmaceutical, biomedical, and advanced materials sectors who require precise molecular encapsulation coupled with a reactive handle for further chemical modification.

Application

• Drug Delivery Systems: As a functional excipient for creating covalent drug-polymer conjugates or cross-linked hydrogel networks for controlled release.
• Bioconjugation & Protein Modification: For site-specific attachment of the cyclodextrin cavity to peptides, proteins, or antibodies via thiol-maleimide or disulfide chemistry.
• Surface Engineering & Biosensors: Immobilization onto gold or other surfaces via thiol-gold interactions to create functional layers for sensing or catalysis.
• Polymer & Nanomaterial Synthesis: Acting as a multi-thiol cross-linker or initiator in the synthesis of smart polymers, dendrimers, or molecularly imprinted polymers.
• Analytical Chemistry: Used as a chiral stationary phase modifier or a selective agent in capillary electrophoresis for enantiomer separation.
• Catalysis: As a ligand or support for metal nanoparticles, utilizing the thiol groups for stabilization and the cavity for substrate selectivity.

Basic Information

Product Name	Hexakis-(6-Mercapto-6-Deoxy)-α-Cyclodextrin
CAS No.	180839-60-5
Molecular Formula	C36H60O24S6
Molecular Weight	1093.22 g/mol
Synonyms	6-Mercapto-α-cyclodextrin; α-Cyclodextrin, 6-mercapto-6-deoxy-; Per-6-thio-α-cyclodextrin; Hexakis(6-deoxy-6-mercapto)-α-cyclodextrin; 6-SH-α-CD; α-CD-SH; Thiolated α-cyclodextrin; 6-Thio-α-cyclodextrin
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and development. Each batch is characterized to confirm identity, purity, and functional thiol content. Certificates of Analysis (COA) are available upon request, detailing parameters such as assay, degree of substitution, and impurity profiles. We adhere to cGMP principles where applicable to support pharmaceutical and advanced material applications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place. This compound is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures will lead to degradation and disulfide formation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Degree of Substitution (Titration)	5.5 - 6.0 (per molecule)
Water Content (KF)	≤ 5.0 %
Residue on Ignition	≤ 0.5 %
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.