Description

Cathepsin Inhibitor Ii is a potent and selective cell-permeable inhibitor of cathepsin L, a cysteine protease involved in numerous physiological and pathological processes. This high-purity biochemical tool is essential for researchers investigating proteolytic pathways, protein degradation, and intracellular signaling. It is primarily utilized in pharmaceutical R&D, academic life science research, and biotechnology for target validation and mechanistic studies in areas such as cancer, osteoporosis, and infectious diseases.

Application

• Biomedical Research: Used as a key pharmacological tool to study the role of cathepsin L in cellular processes like apoptosis, autophagy, and antigen presentation.
• Drug Discovery & Target Validation: Serves as a reference compound in high-throughput screening assays and for validating cathepsin L as a therapeutic target in oncology and bone disorders.
• Protease Mechanism Studies: Employed in enzymology to elucidate the kinetics, specificity, and inhibition mechanisms of cysteine cathepsins.
• Inflammatory & Infectious Disease Models: Applied in research models to investigate the contribution of cathepsin L to inflammatory responses and viral entry mechanisms (e.g., SARS-CoV).
• Biochemical Assay Development: Acts as a control inhibitor in the development and optimization of fluorescence-based or colorimetric protease activity assays.

Basic Information

Product Name	Cathepsin Inhibitor Ii
CAS No.	180313-87-5
Molecular Formula	C₁₄H₁₅N₃O₃S₂
Molecular Weight	337.42 g/mol
Synonyms	Z-Phe-Tyr(t-Bu)-diazomethyl ketone; Z-FY(t-Bu)-CHN₂; Cathepsin L Inhibitor II; Z-Phe-Tyr(tBu)-diazomethylketone; Benzyloxycarbonyl-Phe-Tyr(t-butyl)-diazomethyl ketone; (2S)-2-[[(2S)-2-[[(2S)-3-Phenyl-2-(phenylmethoxycarbonylamino)propanoyl]amino]-3-[4-[(2-methylpropan-2-yl)oxy]phenyl]propanoyl]amino]-3-sulfanylpropanoic acid (IUPAC); Cbz-Phe-Tyr(tBu)-diazomethyl ketone
EINECS	Contact for details

Quality Control

Our Cathepsin Inhibitor Ii is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, potency, and analytical data is provided with every shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C. Allow the product to equilibrate to room temperature before opening to minimize moisture condensation. Keep away from strong oxidizers and bases.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Potency (Enzymatic Assay)	≥ 95%
Solubility	Soluble in DMSO, DMF; slightly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.