Description

Cathepsin Inhibitor Iii CAS NO 180313-86-4 is a potent and selective small molecule inhibitor of cathepsin proteases, a key class of enzymes involved in protein degradation and cellular signaling pathways. This compound is critical for researchers and developers in life sciences and pharmaceutical discovery, providing a reliable tool for modulating protease activity in complex biological systems. It is primarily utilized in biochemical research, target validation, and the development of novel therapeutic agents for conditions involving dysregulated proteolysis.

Application

• Biochemical Research: Used as a specific tool compound to study the function and inhibition kinetics of cathepsin enzymes in vitro.
• Drug Discovery & Target Validation: Serves as a reference standard and pharmacologic probe in high-throughput screening and lead optimization campaigns targeting cathepsins.
• Cancer Research: Investigated for its potential to inhibit tumor invasion, metastasis, and angiogenesis by blocking cathepsin-mediated extracellular matrix degradation.
• Inflammatory & Autoimmune Disease Models: Applied in research exploring the role of cathepsins in immune cell signaling, antigen presentation, and inflammatory tissue damage.
• Neuroscientific Studies: Utilized in models of neurodegenerative diseases to examine protease involvement in neuronal apoptosis and protein aggregate clearance.
• Infectious Disease Research: Employed to study host-pathogen interactions where cathepsins are utilized for pathogen entry or replication.

Basic Information

Product Name	Cathepsin Inhibitor Iii
CAS No.	180313-86-4
Molecular Formula	C₁₄H₁₅N₃O₃S
Molecular Weight	305.35 g/mol
Synonyms	Cathepsin Inhibitor III; Z-Phe-Tyr(t-Bu)-diazomethyl ketone; Z-FY(t-Bu)-CHN₂; Benzyloxycarbonyl-Phe-Tyr(t-Bu)-diazomethyl ketone; Cathepsin L Inhibitor III; (2S)-2-[[(2S)-2-[[(2S)-2-Benzyloxycarbonylamino-3-phenyl-propanoyl]amino]-3-[4-(tert-butoxy)phenyl]propanoyl]amino]-3-phenylpropanehydrazonic acid diazo derivative; Z-Phe-Tyr(O-t-Bu)-CHN₂; Protease Inhibitor III
EINECS	Contact for details

Quality Control

Our Cathepsin Inhibitor III is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and spectroscopic identification (NMR, MS). A detailed Certificate of Analysis (COA) documenting identity, purity, and potency is provided with every shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.