Description

1400W CAS NO 180001-34-7 is a highly selective and potent inhibitor of inducible nitric oxide synthase (iNOS). This compound is a critical research tool for studying the role of nitric oxide (NO) signaling in various physiological and pathological processes. It is essential for researchers and developers in the fields of immunology, neuroscience, and cardiovascular disease, where precise modulation of iNOS activity is required. Its targeted action makes it invaluable for both basic scientific discovery and the development of novel therapeutic agents.

Application

• Biomedical Research: A fundamental tool for investigating the specific role of iNOS-derived nitric oxide in cellular models of inflammation, sepsis, and neurodegenerative diseases.
• Pharmacology & Drug Discovery: Used as a reference standard and active compound in screening assays to identify and validate new iNOS-targeting therapeutics.
• Immunology Studies: Employed to dissect the contribution of iNOS to macrophage activation, T-cell function, and other immune responses.
• Neuroscience Research: Applied in models of stroke, Parkinson's disease, and neuropathic pain to understand the neurotoxic and neuroprotective roles of NO.
• Cardiovascular Research: Utilized to study the involvement of iNOS in conditions such as atherosclerosis, hypertension, and heart failure.
• Inflammatory Disease Models: Critical for preclinical research in arthritis, asthma, and inflammatory bowel disease to evaluate the efficacy of iNOS inhibition.

Basic Information

Product Name	1400W
CAS No.	180001-34-7
Molecular Formula	C9H21N5O3S
Molecular Weight	279.36 g/mol
Synonyms	N-[(3-Aminomethyl)phenyl]methyl]ethanimidamide; 1400W Dihydrochloride; N-[[3-(Aminomethyl)phenyl]methyl]ethanimidamide; iNOS Inhibitor 1400W; 1400W (iNOS inhibitor); GW-1400W; L-N6-(1-Iminoethyl)lysine 5-tetrazole amide; A potent and selective inhibitor of inducible nitric oxide synthase
EINECS	Contact for details

Quality Control

Our 1400W is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and spectroscopic identification (NMR, MS). A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with our stringent internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.