Description

2,4-Difluorobenzylsulfonyl Chloride is a high-purity, reactive organosulfur building block essential for advanced chemical synthesis. Its value lies in its dual functionality as a sulfonyl chloride, enabling the introduction of the sulfonyl group, and its difluorinated benzyl moiety, which can impart desirable metabolic stability and lipophilicity to target molecules. This compound is critically needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of sulfonamide-based drug candidates, including kinase inhibitors, protease inhibitors, and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the development of new generation herbicides, fungicides, and pesticides where the difluorobenzyl group enhances biological activity and environmental stability.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers, coatings, and advanced functional materials.
• Chemical Biology Probes: Employed to create activity-based probes (ABPs) and affinity labels for studying enzyme function and target identification.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	2,4-Difluorobenzylsulfonyl Chloride
CAS No.	179524-68-6
Molecular Formula	C7H5ClF2O2S
Molecular Weight	226.63 g/mol
Synonyms	2,4-Difluorobenzylsulfonyl chloride; 1-(Chlorosulfonyl)methyl-2,4-difluorobenzene; (2,4-Difluorophenyl)methanesulfonyl chloride; α,2,4-Trifluorotoluene-α-sulfonyl chloride; 2,4-Difluoro-α-toluenesulfonyl chloride; 2,4-DFBSC; 2,4-Difluorobenzyl sulfone chloride
EINECS	Contact for details

Quality Control

Our 2,4-Difluorobenzylsulfonyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.