Description

2,5-Difluorobenzylsulfonyl Chloride is a high-purity, reactive organosulfur intermediate essential for advanced chemical synthesis. This compound matters for its role as a key building block in the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. It is primarily needed by R&D chemists and process development scientists working on sulfonamide-based active ingredients, novel materials, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel sulfonamide-based drug candidates, including kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, where the difluorobenzyl moiety confers specific biological activity and stability.
• Material Science Research: Serves as a monomer or cross-linking agent in the creation of specialized polymers and advanced functional materials.
• Chemical Biology & Proteomics: Employed as a reactive handle for bioconjugation and the development of chemical probes targeting specific enzymes or proteins.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects requiring the introduction of a sulfonyl chloride group onto a difluorinated aromatic scaffold.

Basic Information

Product Name	2,5-Difluorobenzylsulfonyl Chloride
CAS No.	179524-62-0
Molecular Formula	C7H5ClF2O2S
Molecular Weight	226.63 g/mol
Synonyms	2,5-Difluorophenylmethanesulfonyl chloride; 1-(Chlorosulfonyl)methyl-2,5-difluorobenzene; α-(Chlorosulfonyl)-2,5-difluorotoluene; 2,5-Difluorobenzyl sulfonyl chloride; (2,5-Difluorophenyl)methanesulfonyl chloride; Benzene, 1-(chlorosulfonyl)methyl-2,5-difluoro-; 2,5-Difluoro-α-toluenesulfonyl chloride
EINECS	Contact for details

Quality Control

Our 2,5-Difluorobenzylsulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and titration methods, to ensure high purity and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.