Description

(2,6-Difluorophenyl)Methylsulphonyl Chloride CAS NO 179524-60-8 is a high-purity organosulfur reagent featuring a reactive sulphonyl chloride group and a difluorinated aromatic ring. This compound is critical for introducing the (2,6-difluorophenyl)methylsulfonyl moiety into target molecules, enabling the synthesis of advanced chemical entities. It is primarily sought by R&D and production teams in the pharmaceutical and agrochemical industries for developing novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing sulfonamide-based drug candidates, including potential kinase inhibitors and enzyme modulators.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the difluorophenylsulfonyl group confers specific biological activity and stability.
• Material Science Research: Employed in the development of specialty polymers and functional materials that require sulfonyl chloride coupling chemistry.
• Chemical Biology Probes: Serves as a reagent for labeling and modifying biomolecules in proteomics and biochemical research due to its electrophilic reactivity.
• Custom Synthesis & Contract Manufacturing: A vital starting material for fine chemical manufacturers offering bespoke synthesis services to the life sciences sector.

Basic Information

Product Name	(2,6-Difluorophenyl)Methylsulphonyl Chloride
CAS No.	179524-60-8
Molecular Formula	C7H5ClF2O2S
Molecular Weight	226.63 g/mol
Synonyms	2,6-Difluorobenzylsulfonyl Chloride; (2,6-Difluorophenyl)methanesulfonyl Chloride; 2,6-Difluoro-α-toluenesulfonyl Chloride; 1-(Chlorosulfonyl)methyl-2,6-difluorobenzene; α,2,6-Trifluorotoluene-α-sulfonyl Chloride; (2,6-Difluorobenzyl)sulfonyl Chloride; 2,6-Difluorophenylmethylsulfonyl Chloride
EINECS	Contact for details

Quality Control

Our (2,6-Difluorophenyl)Methylsulphonyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and Karl Fischer titration, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.