Description

5-tert-Butylthiophene-2-Sulfonyl Chloride is a high-purity, reactive organosulfur intermediate essential for advanced chemical synthesis. Its core value lies in its sulfonyl chloride functional group, which enables efficient sulfonylation and sulfonamide formation reactions under controlled conditions. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of sulfonamide-based therapeutics.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that incorporate the thiophene-sulfonyl moiety.
• Material Science Research: Serves as a precursor for functionalized polymers, ligands for catalysis, and advanced organic electronic materials.
• Chemical Biology & Proteomics: Employed as a reactive handle for bioconjugation, labeling, and the development of activity-based probes.
• Custom Synthesis & Contract Manufacturing: A critical reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Item	Details
Product Name	5-tert-Butylthiophene-2-Sulfonyl Chloride
CAS No.	179400-17-0
Molecular Formula	C9H13ClO2S2
Molecular Weight	252.77 g/mol
Synonyms	2-Thiophenesulfonyl chloride, 5-(1,1-dimethylethyl)-; 5-tert-Butyl-2-thiophenesulfonyl chloride; 5-(tert-Butyl)thiophene-2-sulfonyl chloride; 5-tert-Butylthiophene-2-sulphonyl chloride; 2-Thiophenesulfonyl chloride, 5-tert-butyl-; 179400-17-0; tert-Butylthiophenesulfonyl chloride
EINECS	Contact for details

Quality Control

Our 5-tert-Butylthiophene-2-Sulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.