Description

5-Methyl-Pyridine-2-Sulfonyl Chloride is a versatile and reactive organosulfur compound used as a key sulfonylation reagent and building block in advanced organic synthesis. Its primary value lies in its ability to introduce the 5-methyl-pyridine-2-sulfonyl moiety, a functional group of significant interest in medicinal chemistry and materials science. This intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of drug candidates, particularly in the development of kinase inhibitors, receptor antagonists, and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and insecticides, where the sulfonyl chloride group enables the formation of sulfonamides and sulfonate esters.
• Material Science Research: Serves as a precursor for functionalized polymers, liquid crystals, and metal-organic frameworks (MOFs) requiring specific sulfonyl-based ligands.
• Chemical Biology & Proteomics: Employed in the design of activity-based probes (ABPs) and affinity labels to study enzyme function and protein interactions.
• Custom Synthesis & Contract Manufacturing: A valuable reagent for custom chemical synthesis (CDMO) services catering to R&D and pilot-scale production.

Basic Information

Product Name	5-Methyl-Pyridine-2-Sulfonyl Chloride
CAS No.	179400-16-9
Molecular Formula	C6H6ClNO2S
Molecular Weight	191.64 g/mol
Synonyms	2-Picoline-5-sulfonyl chloride; 5-Methyl-2-pyridinesulfonyl chloride; 2-Pyridinesulfonyl chloride, 5-methyl-; 5-Methylpyridine-2-sulfonyl chloride; 5-Methyl-2-picolinesulfonyl chloride; 2-Sulfonylchloride-5-methylpyridine
EINECS	Contact for details

Quality Control

Our 5-Methyl-Pyridine-2-Sulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.