Description

Z-Leu-Leu-Leu-B(Oh)2 (Mg262) is a specialized tripeptide boronic acid derivative, a potent and selective proteasome inhibitor. This compound is of significant value in biochemical and pharmaceutical research for its role in studying cellular protein degradation pathways. It is primarily needed by research institutions and pharmaceutical companies engaged in oncology, immunology, and neurodegenerative disease research, as well as by manufacturers of high-purity biochemical reagents.

Application

• Biochemical Research: A critical tool for studying the 26S proteasome complex and the ubiquitin-proteasome pathway in vitro and in cell-based assays.
• Pharmaceutical Development: Serves as a reference standard and a key intermediate in the discovery and development of novel therapeutic agents targeting proteasome activity.
• Cancer Research: Used to investigate mechanisms of apoptosis and cell cycle arrest, providing insights for potential anti-cancer drug candidates.
• Enzyme Inhibition Studies: Acts as a specific, covalent inhibitor for characterizing proteasome function and validating assay systems.
• High-Purity Reagent Production: Supplied to manufacturers for formulation into specialized research kits and assay components.
• Academic Research: Utilized in university and institutional labs for fundamental studies in cell biology, protein turnover, and disease mechanisms.

Basic Information

Product Name	Z-Leu-Leu-Leu-B(Oh)2 (Mg262)
CAS No.	179324-22-2
Molecular Formula	C₂₇H₄₄BN₃O₈
Molecular Weight	549.46 g/mol
Synonyms	Z-LLL-B(OH)2; MG-262; Bortezomib Intermediate; Z-Leu-Leu-Leu-boronic acid; Benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucine boronic acid; (1R)-1-[[(2S)-1-[[(2S)-1-[[(2S)-2-Amino-4-methyl-1-oxopentyl]amino]-4-methyl-1-oxopentyl]amino]-4-methyl-1-oxopentyl]amino]-3-boranyl-1-oxopropan-2-aminium; Proteasome Inhibitor MG262
EINECS	Contact for details

Quality Control

Our Z-Leu-Leu-Leu-B(Oh)2 (Mg262) is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing including HPLC, NMR, and MS for identity confirmation and purity verification. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive). For long-term storage, consider under an inert atmosphere. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥95.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.