Description

Z-Leu-Leu-Boroleu-Pinanediol (Mg261) is a specialized, high-purity boronic acid derivative designed for advanced research and development. This compound is a critical building block and potent proteasome inhibitor, offering significant value in biochemical and pharmaceutical discovery. It is primarily utilized by researchers and manufacturers in the fields of medicinal chemistry, proteomics, and drug development for creating novel therapeutic agents and studying cellular degradation pathways.

Application

• Proteasome Inhibition Research: Serves as a key tool compound for studying the ubiquitin-proteasome pathway, a crucial target in cancer and neurodegenerative disease research.
• Medicinal Chemistry & Drug Discovery: Acts as a sophisticated building block for the synthesis of novel boronic acid-based drug candidates, particularly protease inhibitors.
• Biochemical Assay Development: Used in the development and validation of high-throughput screening assays to identify and characterize new proteasome inhibitors.
• Academic & Pharmaceutical R&D: Essential for fundamental research in cell biology, apoptosis studies, and the development of targeted therapies.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	Z-Leu-Leu-Boroleu-Pinanediol (Mg261)
CAS No.	179324-21-1
Molecular Formula	C31H48BN3O7
Molecular Weight	585.55 g/mol
Synonyms	Z-LLL-Boroleu-Pinanediol; MG-261; Z-Leu-Leu-Leu-Boronic Acid Pinanediol Ester; Bortezomib Intermediate; Proteasome Inhibitor MG261; (1S,2R,3S,5S)-3-(2-((S)-1-((S)-2-((((Benzyloxy)carbonyl)amino)-4-methylpentanamido)-4-methylpentanamido)-3-cyclohexylpropanamido)propyl)-6,6-dimethylbicyclo[3.1.1]heptane-2,3-diol; Carbamic acid, N-[(1S)-1-[[(1S)-1-[[(1S)-1-[[(1S,2R,3S,5S)-2,3-dihydroxy-6,6-dimethylbicyclo[3.1.1]hept-2-yl]methyl]butyl]borono]amino]-3-cyclohexyl-1-oxopropyl]-4-methylpentyl]-4-methyl-, phenylmethyl ester
EINECS	Contact for details

Quality Control

Our Z-Leu-Leu-Boroleu-Pinanediol (Mg261) is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.