Description

Phccc CAS NO 179068-02-1 is a high-purity chemical compound, specifically a selective and potent negative allosteric modulator of the metabotropic glutamate receptor subtype 5 (mGluR5). This compound is crucial for advanced neuroscience research and pharmaceutical development, enabling precise modulation of glutamate signaling pathways. It is primarily utilized by research institutions, pharmaceutical R&D departments, and contract research organizations (CROs) focused on neurological disorders, psychiatric conditions, and drug discovery.

Application

• Neuroscience Research: As a key pharmacological tool for studying the role of mGluR5 in synaptic plasticity, learning, and memory.
• Drug Discovery Programs: Used in high-throughput screening (HTS) and lead optimization for developing novel therapeutics targeting neurological and psychiatric diseases.
• Preclinical Studies: Employed in animal models to investigate potential treatments for conditions such as anxiety, depression, Fragile X syndrome, and Parkinson's disease.
• Biochemical Assays: Serves as a reference standard in receptor binding and functional assays to characterize new chemical entities.
• Academic Research: Facilitates basic research in university laboratories exploring glutamate receptor biology and signal transduction mechanisms.

Basic Information

Product Name	Phccc
CAS No.	179068-02-1
Molecular Formula	C12H12N4O3
Molecular Weight	260.25 g/mol
Synonyms	PHCCC; (S)-3,4-DCPG; (S)-3,4-Dicarboxyphenylglycine; (S)-4-Carboxy-3-hydroxyphenylglycine; N-Phenyl-1,2,3,4-tetrahydro-1-isoquinolinecarboxamide; mGluR5 Negative Allosteric Modulator; 179068-02-1
EINECS	Contact for details

Quality Control

Our Phccc is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, essential for reliable research outcomes. Each lot undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications. We support compliance with various research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.