Description

2,4-Difluoro-5-Nitrotoluene is a versatile fluorinated aromatic intermediate of significant importance in advanced organic synthesis. Its value lies in the strategic positioning of its fluorine and nitro substituents, which enable precise chemical transformations for creating complex molecular architectures. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly in the development of new drugs where fluorine atoms are used to modulate bioavailability, metabolic stability, and binding affinity.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the difluoro-nitrotoluene core contributes to the efficacy and environmental profile of the final product.
• Material Science Precursor: Serves as a monomer or intermediate in the synthesis of specialty polymers, liquid crystals, and advanced organic electronic materials that require fluorinated aromatic units.
• Dye and Pigment Manufacturing: Acts as a starting material for the creation of novel, light-fast fluorinated dyes and organic pigments.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) due to the presence of reactive halogens, facilitating the construction of complex biaryl systems.
• Nucleophilic Aromatic Substitution: The nitro and fluorine groups activate the aromatic ring for selective nucleophilic substitution, allowing for the introduction of a wide variety of functional groups.

Basic Information

Product Name	2,4-Difluoro-5-Nitrotoluene
CAS No.	179011-38-2
Molecular Formula	C7H5F2NO2
Molecular Weight	173.12 g/mol
Synonyms	1-Methyl-2,4-difluoro-5-nitrobenzene; 5-Nitro-2,4-difluorotoluene; 2,4-Difluoro-1-methyl-5-nitrobenzene; Toluene, 2,4-difluoro-5-nitro-; Benzene, 1-methyl-2,4-difluoro-5-nitro-
EINECS	Contact for details

Quality Control

Every batch of our 2,4-Difluoro-5-Nitrotoluene undergoes rigorous analytical testing to ensure it meets the high-purity standards required for sensitive synthetic applications. Our quality assurance protocols are designed to guarantee batch-to-batch consistency and reliability for your process development and scale-up activities. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.