Description

Carbonic Anhydrase Ix/Xii Inhibitor Ii(U-104) is a potent and selective small molecule inhibitor designed to target specific isoforms of the carbonic anhydrase enzyme family. This compound matters for researchers and developers focused on modulating pH-dependent biological processes, particularly in hypoxic tumor microenvironments. It is needed by pharmaceutical R&D teams, academic research institutions, and biotechnology companies engaged in oncology, diagnostic imaging, and metabolic disorder research. The product is supplied as a high-purity reference standard and research chemical.

Application

• Oncology Research: Investigation of tumor acidosis and the role of CA IX/XII in cancer cell survival, proliferation, and metastasis.
• Diagnostic Probe Development: Serves as a lead compound for developing non-invasive imaging agents to detect hypoxic tumors.
• Mechanistic Studies: Tool for elucidating the physiological and pathological functions of membrane-associated carbonic anhydrase isoforms.
• Preclinical Drug Discovery: Used in vitro and in vivo to validate CA IX/XII as therapeutic targets and to assess the efficacy of novel inhibitor scaffolds.
• Biochemical Assays: High-purity standard for enzyme inhibition assays and high-throughput screening campaigns.

Basic Information

Product Name	Carbonic Anhydrase Ix/Xii Inhibitor Ii(U-104)
CAS No.	178606-66-1
Molecular Formula	C₁₄H₁₀F₃N₃O₃S
Molecular Weight	357.31 g/mol
Synonyms	U-104; 4-[(4-Fluorophenyl)sulfonyl]-2-(trifluoromethyl)benzamide; N-Hydroxy-4-[(4-fluorophenyl)sulfonyl]-2-(trifluoromethyl)benzamide; CA IX/XII Inhibitor II; Carbonic Anhydrase Inhibitor U-104; 2-(Trifluoromethyl)-4-[(4-fluorophenyl)sulfonyl]benzhydroxamic acid
EINECS	Contact for details

Quality Control

Our Carbonic Anhydrase Ix/Xii Inhibitor Ii(U-104) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity confirmation and spectroscopic identification (NMR, MS), to ensure consistency and reliability for research applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This compound is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.