Description

Ac-Yvad-Cmk is a potent, cell-permeable, and irreversible inhibitor of caspase-1 (ICE, Interleukin-1β Converting Enzyme). This compound is a critical research tool for studying the role of caspase-1 in inflammatory pathways and programmed cell death (pyroptosis). It is essential for researchers and developers in the pharmaceutical and biotechnology sectors focused on inflammation, autoimmune diseases, and novel therapeutic discovery.

Application

• Biochemical Research: A standard tool for specifically inhibiting caspase-1 activity in in vitro enzyme assays and cell-based studies to elucidate inflammatory signaling cascades.
• Pharmaceutical R&D: Used in target validation and screening assays during the discovery phase of anti-inflammatory drugs and therapies for conditions like sepsis, rheumatoid arthritis, and gout.
• Immunology Studies: Employed to investigate the maturation and secretion of pro-inflammatory cytokines, specifically IL-1β and IL-18, in immune cells such as macrophages.
• Cell Death Research: Crucial for differentiating between apoptosis and pyroptosis (caspase-1-dependent inflammatory cell death) in various disease models.
• Academic Research: A key reagent in university and institutional labs for fundamental research on innate immunity and inflammasome biology.

Basic Information

Product Name	Ac-Yvad-Cmk
CAS No.	178603-78-6
Molecular Formula	C24H33ClN4O7
Molecular Weight	525.00 g/mol
Synonyms	Ac-Tyr-Val-Ala-Asp-chloromethylketone; Ac-YVAD-CMK; Ac-YVAD-CHO (common misnomer for aldehyde analog); Acetyl-Tyr-Val-Ala-Asp-chloromethyl ketone; Caspase-1 Inhibitor II; ICE Inhibitor II; Interleukin-1β Converting Enzyme Inhibitor; N-Acetyl-Tyr-Val-Ala-Asp-CMK
EINECS	Contact for details

Quality Control

Our Ac-Yvad-Cmk is manufactured under strict quality protocols suitable for research applications. Each batch undergoes comprehensive analytical testing including HPLC for purity verification and mass spectrometry for structural confirmation. Certificates of Analysis (COA) detailing purity, identity, and batch-specific data are available upon request to ensure traceability and reliability for your critical research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; Slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.