Description

5-((2S)Pyrrolidin-2-Yl)-3-Fluoropyridine CAS NO 177745-40-3 is a high-purity, chiral fluorinated heterocyclic compound that serves as a critical building block in modern pharmaceutical research and development. Its unique structure, featuring a stereogenic center and a fluorine atom, makes it a valuable scaffold for creating novel bioactive molecules with enhanced metabolic stability and binding affinity. This advanced intermediate is primarily sought by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the synthesis of potential drug candidates targeting central nervous system disorders, oncology, and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in neuroscience and oncology.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization to introduce fluorinated pyrrolidine motifs into drug-like molecules.
• Ligand Synthesis: Employed in the preparation of sophisticated ligands for catalysis or as probes in biochemical assays.
• Process Chemistry: Serves as a starting material or intermediate in the scale-up and route development for complex target molecules.
• Chemical Biology: Utilized for the synthesis of molecular tools and probes to study biological systems and enzyme function.
• Academic Research: A valuable compound for universities and research institutes exploring new synthetic methodologies and fluorine chemistry.

Basic Information

Product Name	5-((2S)Pyrrolidin-2-Yl)-3-Fluoropyridine
CAS No.	177745-40-3
Molecular Formula	C9H11FN2
Molecular Weight	166.20 g/mol
Synonyms	3-Fluoro-5-[(2S)-2-pyrrolidinyl]pyridine; (S)-3-Fluoro-5-(pyrrolidin-2-yl)pyridine; 3-Fluoro-5-((S)-pyrrolidin-2-yl)pyridine; 5-((2S)-Pyrrolidin-2-yl)-3-fluoropyridine; 3-Fluoro-5-(2S-pyrrolidinyl)pyridine; 5-[(2S)-2-Pyrrolidinyl]-3-fluoropyridine; (2S)-2-(5-Fluoro-3-pyridinyl)pyrrolidine
EINECS	Contact for details

Quality Control

Our 5-((2S)Pyrrolidin-2-Yl)-3-Fluoropyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical R&D. We provide detailed Certificates of Analysis (COA) with each shipment, documenting critical parameters such as assay, enantiomeric excess, and impurity profiles. Our quality commitment aligns with cGMP principles for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.