Description

Phccc CAS NO 177610-87-6 is a high-purity, non-peptide small molecule compound of significant interest in advanced biochemical research. Its primary value lies in its potent and selective activity as a negative allosteric modulator of the metabotropic glutamate receptor subtype 5 (mGluR5). This makes it an essential research tool for neuroscientists and pharmacologists investigating neurological pathways, synaptic plasticity, and potential therapeutic targets. Key industries and applications include pharmaceutical R&D for CNS disorders, academic neuroscience studies, and the development of novel neuropharmacological probes.

Application

• Neuroscience Research: Used as a selective mGluR5 negative allosteric modulator (NAM) to study receptor function, signal transduction, and its role in neurological conditions.
• Pharmacological Profiling: Serves as a reference standard and active compound in high-throughput screening (HTS) assays for drug discovery targeting glutamate receptors.
• Study of CNS Disorders: Applied in preclinical research models for conditions such as anxiety, depression, Fragile X syndrome, Parkinson's disease, and chronic pain, where mGluR5 is implicated.
• Biochemical Mechanism Studies: Utilized to investigate allosteric modulation, synaptic plasticity, and long-term depression (LTD) in neural circuits.
• Academic & Institutional R&D: A critical reagent for universities and research institutes focused on neuropharmacology and cellular signaling pathways.
• Pharmaceutical Development: Acts as a lead compound or chemical tool in the early-stage development of potential therapeutics targeting mGluR5.

Basic Information

Product Name	Phccc
CAS No.	177610-87-6
Molecular Formula	C₁₄H₁₀Cl₂N₂O₂
Molecular Weight	309.15 g/mol
Synonyms	PHCCC; 6-Methyl-2-(phenylazo)-3-pyridinol; N-Phenyl-N'-(6-chloro-3-pyridazinyl)urea; 6-Methyl-2-(phenylazo)pyridin-3-ol; mGluR5 Negative Allosteric Modulator; (3-Hydroxy-6-methyl-2-phenylpyridin-4-yl)(phenyl)methanone (common misassignment, verify structure); Allosteric mGlu5 Receptor Antagonist
EINECS	Contact for details

Quality Control

Our Phccc is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment and spectroscopic confirmation (NMR, MS) of identity. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all relevant specifications. For specialized applications, we can supply material that meets the stringent requirements of pharmaceutical R&D and in-vivo studies.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (HPLC)	Retention time matches reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.