Description

8-Iso Prostaglandin F2Beta is a specific isoprostane, a class of prostaglandin-like compounds formed in vivo from the free radical-catalyzed peroxidation of arachidonic acid. This compound is of significant value as a biomarker for oxidative stress and a critical tool in biochemical research. It is primarily needed by pharmaceutical R&D laboratories, clinical diagnostic developers, and academic research institutions studying lipid peroxidation, inflammation, and related disease mechanisms.

Application

• Biomarker Standard for Oxidative Stress: Used as a reference standard in LC-MS/MS and ELISA assays to quantify lipid peroxidation in biological samples (plasma, urine, tissues).
• Pharmaceutical Research: Employed in drug discovery and development programs targeting diseases associated with oxidative damage, such as cardiovascular disorders, neurodegenerative diseases, and metabolic syndromes.
• Clinical Diagnostics Development: Serves as a critical calibrant and quality control material in the development and validation of diagnostic kits for measuring isoprostane levels.
• Mechanistic Biochemical Studies: Utilized in vitro and in vivo to investigate the pathophysiological roles of isoprostanes in inflammation, vasoconstriction, and cell signaling pathways.
• Nutritional & Cosmetic Science Research: Applied in studies evaluating the efficacy of antioxidants, nutraceuticals, and topical formulations in reducing oxidative stress markers.

Basic Information

Product Name	8-Iso Prostaglandin F2Beta
CAS No.	177020-26-7
Molecular Formula	C₂₀H₃₄O₅
Molecular Weight	354.48 g/mol
Synonyms	8-iso-PGF2β; 8-iso-Prostaglandin F2β; 15-F2t-IsoP; 8-epi-PGF2β; 5-[(1S,2E,3S,5S)-3,5-Dihydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]cyclopentyl]pentanoic acid; 8-iso Prostaglandin F2β; F2-Isoprostane; iPF2β-III
EINECS	Contact for details

Quality Control

Our 8-Iso Prostaglandin F2Beta is produced and handled under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the exacting standards required for research and diagnostic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay results, and analytical methods is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. Keep the container in a dry, well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.