Description

Bisindolylmaleimide I Hydrochloride is a potent, cell-permeable, and selective inhibitor of protein kinase C (PKC). This compound is a critical research tool for elucidating the role of PKC isoforms in cellular signaling pathways, apoptosis, and disease mechanisms. It is primarily utilized by researchers and scientists in the fields of biochemistry, pharmacology, and oncology for in vitro and in vivo studies.

Application

• Biochemical Research: A selective inhibitor for studying the structure, function, and regulation of Protein Kinase C (PKC) isoforms.
• Signal Transduction Studies: Used to investigate PKC-mediated pathways in cell proliferation, differentiation, and apoptosis.
• Pharmacological Screening: Serves as a reference standard and key reagent in high-throughput screening for novel PKC-targeting therapeutics.
• Oncology Research: Employed in cancer research to study the role of PKC in tumor progression and as a potential chemotherapeutic target.
• Neuroscience: Applied in studies of PKC involvement in neurotransmitter release, synaptic plasticity, and neurological disorders.
• Cell Biology: A tool compound for modulating PKC activity to understand its impact on cell cycle control and stress responses.

Basic Information

Product Name	Bisindolylmaleimide I Hydrochloride
CAS No.	176504-36-2
Molecular Formula	C25H25ClN4O2
Molecular Weight	448.94 g/mol
Synonyms	Bisindolylmaleimide I HCl; BIM I hydrochloride; GF 109203X hydrochloride; 2-[1-(3-Dimethylaminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)maleimide hydrochloride; PKC Inhibitor, Bisindolylmaleimide I; 3-[1-[3-(Dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione hydrochloride; Ro 31-8220 (related analog); Go 6850 (related analog)
EINECS	Contact for details

Quality Control

Our Bisindolylmaleimide I Hydrochloride is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ISO 9001 quality management standards, and our processes are designed to meet the rigorous demands of the global research community.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm
Solubility	Soluble in DMSO, Methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.