Description

4-Fluoro-2-(Trifluoromethyl)-Benzenesulfonyl Chloride is a high-value, multi-functional chemical building block essential for advanced organic synthesis. Its core value lies in its dual functionality as a sulfonylating and arylating agent, enabling the precise introduction of a fluorinated aromatic sulfonyl moiety into target molecules. This compound is critically needed by R&D and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients, particularly in creating sulfonamide-based drugs and crop protection agents.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of sulfonamide-based drug candidates, including kinase inhibitors, receptor antagonists, and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the fluorinated sulfonyl group enhances biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers, coatings, and advanced materials with specific surface properties.
• Chemical Research & Development: A versatile reagent in academic and industrial labs for exploring new reaction pathways and creating complex molecular architectures.
• Ligand and Catalyst Design: Employed in the synthesis of specialized ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	4-Fluoro-2-(Trifluoromethyl)-Benzenesulfonyl Chloride
CAS No.	176225-09-5
Molecular Formula	C7H3ClF4O2S
Molecular Weight	262.61 g/mol
Synonyms	4-Fluoro-2-(trifluoromethyl)benzenesulfonyl chloride; 2-Trifluoromethyl-4-fluorobenzenesulfonyl chloride; 4-Fluoro-alpha,alpha,α-trifluoro-o-toluenesulfonyl chloride; 1-Fluoro-4-(chlorosulfonyl)-3-(trifluoromethyl)benzene; Benzenesulfonyl chloride, 4-fluoro-2-(trifluoromethyl)-; 4-Fluoro-2-trifluoromethylbenzenesulfonyl chloride; 4-Fluoro-α,α,α-trifluoro-o-toluenesulfonyl chloride
EINECS	Contact for details

Quality Control

Our 4-Fluoro-2-(Trifluoromethyl)-Benzenesulfonyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.