Description

2-Bromo-5-(Trifluoromethyl)Benzenesulfonyl Chloride is a high-value, multi-functional aromatic sulfonyl chloride derivative. This compound serves as a critical synthetic intermediate, prized for its reactivity and the unique properties imparted by its bromo and trifluoromethyl substituents. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecules, particularly in the synthesis of active pharmaceutical ingredients (APIs) and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of sulfonamide-based drug candidates, leveraging the sulfonyl chloride group for amide bond formation.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Research: Employed in the development of specialty polymers and advanced organic materials requiring specific halogenated aromatic units.
• Chemical Biology Probes: Acts as a reagent for modifying proteins or other biomolecules to study function or create bioconjugates.
• Cross-Coupling Reactions: The bromo substituent makes it a suitable substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to create more complex biaryl structures.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	2-Bromo-5-(Trifluoromethyl)Benzenesulfonyl Chloride
CAS No.	176225-08-4
Molecular Formula	C7H3BrClF3O2S
Molecular Weight	323.51 g/mol
Synonyms	2-Bromo-α,α,α-trifluoro-p-toluenesulfonyl chloride; 2-Bromo-α,α,α-trifluoro-4-methylbenzenesulfonyl chloride; 2-Bromo-5-(trifluoromethyl)benzene-1-sulfonyl chloride; Benzenesulfonyl chloride, 2-bromo-5-(trifluoromethyl)-; 5-(Trifluoromethyl)-2-bromobenzenesulfonyl chloride; 2-Bromo-5-trifluoromethylbenzenesulfonyl chloride; 2-Bromo-α,α,α-trifluoro-p-toluenesulphonyl chloride
EINECS	Contact for details

Quality Control

Our 2-Bromo-5-(Trifluoromethyl)Benzenesulfonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and process-scale applications. We employ advanced analytical techniques including HPLC, GC, NMR, and IR spectroscopy for comprehensive characterization. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.