Description

9-Hydroxymethyl-10-Hydroxy Camptothecin is a high-purity, semi-synthetic derivative of the potent topoisomerase I inhibitor, camptothecin. This compound is valued for its enhanced solubility profile and potential for targeted therapeutic applications, making it a critical intermediate in advanced pharmaceutical research and development. It is primarily sought by research institutions and pharmaceutical companies engaged in the synthesis of novel anticancer agents and prodrug development.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel camptothecin analogs and next-generation anticancer drugs.
• Anticancer Research: Used in biochemical and pharmacological studies to investigate mechanisms of topoisomerase I inhibition and tumor cell apoptosis.
• Prodrug Development: Serves as a precursor for designing water-soluble prodrugs to improve the bioavailability and therapeutic index of camptothecin-based therapies.
• Reference Standard: Employed as a high-purity analytical standard in quality control (QC) and research laboratories for method development and validation.
• Bioconjugation Studies: Utilized in research exploring antibody-drug conjugates (ADCs) and other targeted drug delivery systems due to its modifiable hydroxyl groups.

Basic Information

Product Name	9-Hydroxymethyl-10-Hydroxy Camptothecin
CAS No.	175613-38-4
Molecular Formula	C₂₁H₁₈N₂O₆
Molecular Weight	394.38 g/mol
Synonyms	10-Hydroxy-9-(hydroxymethyl)camptothecin; 9-Hydroxymethyl-10-hydroxycamptothecin; SN-38 M1; Camptothecin, 10-hydroxy-9-(hydroxymethyl)-; 9-HM-10-HC; 9-Hydroxymethyl-10-HC; 10-Hydroxy-9-hydroxymethylcamptothecin
EINECS	Contact for details

Quality Control

Our 9-Hydroxymethyl-10-Hydroxy Camptothecin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (IR, NMR, MS). We provide Certificates of Analysis (COA) with detailed specifications for all critical parameters, ensuring traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	Yellow to light yellow powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.